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Antibiotics are one of the greatest success stories of modern medicine – they have transformed, and indeed prolonged, our lives. But they may now be endangering lives, too. Bacteria are rapidly developing resistance to antibiotics and the length of time that antibiotics will remain effective has been pinned down to just a few decades – a situation so serious that the UK's chief medical officer is again urging the government to add it to the national risk register of civil emergencies. This is the third time in just four months that Prof Dame Sally Davies has highlighted the urgency of the situation.