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As a young theorist in Moscow in 1982, Mikhail Shifman became enthralled with an elegant new theory called supersymmetry that attempted to incorporate the known elementary particles into a more complete inventory of the universe.

"My papers from that time really radiate enthusiasm," said Shifman, now a 63-year-old professor at the University of Minnesota. Over the decades, he and thousands of other physicists developed the supersymmetry hypothesis, confident that experiments would confirm it. "But nature apparently doesn't want it, he said. "At least not in its original simple form."