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The family of a US government scientist who fell to his death from a New York hotel window six decades ago have launched a lawsuit for damages against the CIA, alleging the agency was involved in his murder and a subsequent cover-up.

In one of the most notorious cases in the organisation's history, bioweapons expert Frank Olson died in 1953, nine days after he was given LSD by agency officials without his knowledge.

In the lawsuit, filed in the US district court in Washington on Wednesday, Olson's sons Eric and Nils claim their father was murdered after he witnessed extreme interrogations in which the CIA killed suspects using the biological agents he had developed.