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David Nutt, a prominent and often controversial investigator at Imperial College London, has landed about $800,000 from the U.K.'s Medical Research Foundation to test the active ingredient in "magic mushrooms" as a possible new treatment for depression.

Working with the knowledge that psilocybin has been linked to long-term relief for cases of serious depression, Nutt has lined up a manufacturer able to produce a dose that can be injected in about 30 patients. Investigators will take brain scans of the volunteers to help determine how the therapy works.