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It really happened: Six generations of inbreeding spanning the years 1800 to 1960 caused an isolated population of humans living in the hills of Kentucky to become blue-skinned.

The startlingly blue people, all descendants of a French immigrant named Martin Fugate and still living near his original settlement on the banks of Troublesome Creek when hematologists studied them in the 1960s, turned out to have a rare blood condition called methemoglobinemia. A recessive gene was pairing with itself to change the molecular composition of their blood, making it brown as opposed to red, which tinted their skin blue.