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May 2 2012

Large-Scale Analysis Finds Majority of Clinical Trials Don't Provide Meaningful Evidence


The largest comprehensive analysis of Clinicaltrials.gov finds that clinical trials are falling short of producing high-quality evidence needed to guide medical decision-making.

The analysis, published May 1 in the Journal of the American Medical Association, found the majority of clinical trials is small, and there are significant differences among methodical approaches, including randomizing, blinding and the use of data monitoring committees.

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